| Jornada 1 | 2017-09-02 12:00:16sábado, 02/09/2017 | RCD Espanyol Fem  | 1 - 0 |  Real Betis Fem | Liga F | 17-18 | |
| Jornada 2 | 2017-09-09 12:00:16sábado, 09/09/2017 | Real Betis Fem | 1 - 2 |  Rayo Vallecano Fem | Liga F | 17-18 | |
| Jornada 3 | 2017-09-23 12:00:16sábado, 23/09/2017 | Levante UD Fem  | 0 - 1 | Real Betis Fem | Liga F | 17-18 | |
| Jornada 4 | 2017-10-01 12:00:16domingo, 01/10/2017 | Real Betis Fem | 1 - 0 |  Zaragoza CFF Fem | Liga F | 17-18 | |
| Jornada 5 | 2017-10-07 12:00:16sábado, 07/10/2017 | Fundación Albacete  | 4 - 1 | Real Betis Fem | Liga F | 17-18 | |
| Jornada 6 | 2017-10-14 12:00:16sábado, 14/10/2017 | Real Betis Fem | 4 - 0 |  Real Sociedad | Liga F | 17-18 | |
| Jornada 7 | 2017-10-28 12:00:16sábado, 28/10/2017 | Santa Teresa Fem  | 1 - 2 | Real Betis Fem | Liga F | 17-18 | |
| Jornada 8 | 2017-11-05 12:00:16domingo, 05/11/2017 | Real Betis Fem | 12:00:1612:00 |  Athletic Fem | Liga F | 17-18 | |
| Jornada 9 | 2017-11-12 12:00:16domingo, 12/11/2017 | Valencia Fem  | 5 - 2 | Real Betis Fem | Liga F | 17-18 | |
| Jornada 10 | 2017-11-19 12:00:16domingo, 19/11/2017 | Real Betis Fem | 2 - 4 |  At. Madrid Fem | Liga F | 17-18 | |
| Jornada 11 | 2017-12-02 12:00:16sábado, 02/12/2017 | Barcelona Fem  | 6 - 1 | Real Betis Fem | Liga F | 17-18 | |
| Jornada 12 | 2017-12-06 12:00:16miércoles, 06/12/2017 | Real Betis Fem | 2 - 1 |  Madrid CFF | Liga F | 17-18 | |
| Jornada 13 | 2017-12-10 12:00:16domingo, 10/12/2017 | UD Granadilla  | 2 - 3 | Real Betis Fem | Liga F | 17-18 | |
| Jornada 14 | 2017-12-17 12:00:16domingo, 17/12/2017 | Sport. Huelva  | 0 - 0 | Real Betis Fem | Liga F | 17-18 | |
| Jornada 15 | 2018-01-07 12:00:16domingo, 07/01/2018 | Real Betis Fem | 1 - 0 |  Sevilla FC Fem | Liga F | 17-18 | |
| Jornada 16 | 2018-01-14 12:00:16domingo, 14/01/2018 | Real Betis Fem | 2 - 0 | RCD Espanyol Fem | Liga F | 17-18 | |
| Jornada 17 | 2018-01-28 12:00:16domingo, 28/01/2018 | Rayo Vallecano Fem | 1 - 3 | Real Betis Fem | Liga F | 17-18 | |
| Jornada 18 | 2018-02-04 12:00:16domingo, 04/02/2018 | Real Betis Fem | 2 - 0 | Levante UD Fem | Liga F | 17-18 | |
| Jornada 19 | 2018-02-11 12:00:16domingo, 11/02/2018 | Zaragoza CFF Fem | 1 - 1 | Real Betis Fem | Liga F | 17-18 | |
| Jornada 20 | 2018-02-17 12:00:16sábado, 17/02/2018 | Real Betis Fem | 12:00:1612:00 | Fundación Albacete | Liga F | 17-18 | |
| Jornada 21 | 2018-02-24 12:00:16sábado, 24/02/2018 | Real Sociedad | 1 - 1 | Real Betis Fem | Liga F | 17-18 | |
| Jornada 22 | 2018-03-10 12:00:16sábado, 10/03/2018 | Real Betis Fem | 3 - 0 | Santa Teresa Fem | Liga F | 17-18 | |
| Jornada 23 | 2018-03-17 12:00:16sábado, 17/03/2018 | Athletic Fem | 1 - 0 | Real Betis Fem | Liga F | 17-18 | |
| Jornada 24 | 2018-03-24 12:00:16sábado, 24/03/2018 | Real Betis Fem | 0 - 0 | Valencia Fem | Liga F | 17-18 | |
| Jornada 25 | 2018-04-01 12:00:16domingo, 01/04/2018 | At. Madrid Fem | 1 - 0 | Real Betis Fem | Liga F | 17-18 | |
| Jornada 26 | 2018-04-15 12:00:16domingo, 15/04/2018 | Real Betis Fem | 0 - 2 | Barcelona Fem | Liga F | 17-18 | |
| Jornada 27 | 2018-04-22 12:00:16domingo, 22/04/2018 | Madrid CFF | 0 - 1 | Real Betis Fem | Liga F | 17-18 | |
| Jornada 28 | 2018-04-29 12:00:16domingo, 29/04/2018 | Real Betis Fem | 0 - 1 | UD Granadilla | Liga F | 17-18 | |
| Jornada 29 | 2018-05-05 12:00:16sábado, 05/05/2018 | Real Betis Fem | 0 - 1 | Sport. Huelva | Liga F | 17-18 | |
| Jornada 30 | 2018-05-13 12:00:16domingo, 13/05/2018 | Sevilla FC Fem | 0 - 1 | Real Betis Fem | Liga F | 17-18 | |
| 1/4 Copa Reina | 2018-05-20 12:00:38domingo, 20/05/2018 | Real Betis Fem | 0 - 1 | UD Granadilla | Copa de La Reina | 17-18 | |
| 1/4 Copa Reina | 2018-05-23 22:00:48miércoles, 23/05/2018 | UD Granadilla | 2 - 1 | Real Betis Fem | Copa de La Reina | 17-18 | |
